Sampling accessories like Cannulae are used to take samples from the dissolution test. Choice of cannula is important as the sampling method must not adversely affect the accuracy of the test causing erroneous results.
The USP defines the sampling position as:
”A zone half way between the top of the media and top of the paddle or basket, not less than 1cm from the vessel wall.”
It should be noted that the sampling position is different for 500ml and 900ml tests.
PEEK sampling cannulae are used where there may be a risk of an adverse reaction between the compound in the dissolution test and the normal stainless steel sampling cannulae
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Sampling Accessories Cannulae & Stoppers
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Sampling Cannulae are used to take samples from the dissolution test. Choice of cannula is important as the sampling method must not adversely affect the accuracy of the dissolution test and cause erroneous results.
Key Considerations for sampling accessories:
- Sampling Position – this is important as there can be a concentration of the solution may vary according to the sampling position. The sample should be taken midway between the top of the stirring element and at least 10mm away from the side of the vessel.
- Cannula Length – cannulae vary in length from 4.75” (120mm) to 15” (380mm). There are different lengths for 500ml and 900ml tests as the midpoint will change with the volume. Extended lengths are normally used for “through the head sampling” whereby the cannula passes through the drive head of the dissolution bath.
- Cannula Material – The cannulae are made from either stainless steel or PEEK so that they do not adsorb or interfere with the active ingredient
- Stoppers – cannulae can be used with stoppers during manual sampling to ensure that the sample is always taken from the same depth.
Inconsistency in dissolution sampling can be a major source of errors. Selecting the best sampling cannula for your dissolution tester is not always straightforward which is why our renowned customer service is here to help. Simply Contact us or call us and we will respond right away.