Dissolution Area

This is the area for Semi Automated Dissolution Testing systems.

Semi automated dissolution in this case means auto sampling for a Dissolutin Test Instrument at pre-programmed times. This already eases the dissolution job a lot. After all samples have been dropped the dissolution test proceeds automatically and all samples are simultaneously removed from each connected vessel. The sample is delivered into a connected Fraction Collector by a peristaltic-, syringe-, or valve-less piston pump. The Collector may be the PTFC2 Sampler or the DSR Auto-Sampler which offers online sample Dilution. These systems do not require any software control. Sampling information is entered via the connected PTA Dissolution Bath.

pharma_test_prolyse

ASP2000

Connecting a PTA Dissolution Bath to the ASP-2000 Sample Processing System offers online Dilution and Sample Injection into either a UV/VIS spectrophotometer or a HPLC System. This configuration requires the WinDiss32 software pack to be installed.

Overview

All the shown baths can be upgraded with a Pump and a Fraction Collector, Auto Sampler or Sample Processor.
Below you will find the Dissolution Baths to be upgraded. Please click on the images for more information about performance, accessories, calibration tools and consumables.

Online Systems

We supply semi automated systems as well as fully automated Dissolution solution packages. The latest invention is the IDS-1000 In-Situ Fiber Probe system. As the new DTS-800 its world-wide a unique design because all equipment needed to perform an automated dissolution test is “on board”.

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Phone: +31 (0)162 383100
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ptws-820D dissolution tester

ptws-820D dissolution tester

PTWS-820D – ready for automation

Semi Automated Dissolution Testing

Pharma Test Apparatebau AG announces the release of the first model of its next generation of tablet dissolution testing instruments. The youngest model of this new product line, the PTWS 820D, is available now!.

The PTWS 820D is an 8-position, single-drive compact tablet dissolution testing instrument. It features a completely new set of control electronics with a large color touch screen, reacting on pressure. They use of it with gloves on is no problem. The touch screen controls the various mechanical features of the instrument such as the tool stirring speed, lift drive and heater. The instrument control is menu-driven. Visual signals inform the operator of the status of the critical instrument parameters, e.g., the current bath temperature and a countdown timer for the next sampling interval. Once a test is running, the instrument switches into a “highlight” mode, displaying critical information in an enlarged font. So the screen is readable from a large distance.

The touch screen uses resistive technology (pressure sensitive); therefore, it is easy to be used even when wearing laboratory gloves. User data is stored on an SD card and can be copied to a computer for backup or transferred to another instrument of Pharmatest. This way the storage space for the methods is basically unlimited. It is also possible to perform a quick test directly from the start screen. This is without the need of creating any methods or logging on to the instrument beforehand (this function can be disabled).

The new EPE autosampling manifold of the PTWS 820D with an encased design removes all tubing lines from the working area reducing also failures. The EPE is automatically driven into the programmed sampling position at the interval times, these are stored in memory. The probes remain in the dissolution medium only during the sampling times. The individual temperature probes are part of this.

The new sampling probe design combines the sampling and backflush probes into 1 probe with an inner and an outer tube. It is also reducing the number of holes required in the tablet magazine to help prevent evaporation. The optional media replacement is done through a second tube. The redesigned TM tablet magazine features integrated convex vessel covers. The convex shape causes condensed medium to drop back into the dissolution vessel. The integrated covers seal the vessel thereby reducing any evaporation significantly.

External data logger
Vessel No. : 8 (4 by 2 or 2 by 4 arrangement)
Speed : 20-220Rpm, ±2% of set speed, typically < 1%
Heater Range : 25 – 45°C, ± 0.2°C inside the water bath
Circulation : Water circulated from external heating system through special diffuser inside the water bath.
Dimension : 45 x 75 cm (2 by 4) or 75 x 45 cm (4 by 2)

 


ptws100 dissolutie tester

PTWS-100 series dissolutie tester

DFC 100 including PTWS 100 Bath

Semi Automated Dissolution Testing

Whenever automated sampling from a Dissolution Bath is required the PTFC-2 Fraction Collector together with a pump offers an ideal choice. The control of the PTFC-2 fraction collector with respect to sampling times, dosage volumes, refilling and pump drive is done via the keyboard or testing method filing system of the PTWS 100 dissolution bath. Enter sampling times or call the required method and connect the system components together for a semi automated operation.
Correctly positioned sampling tubes, equal sampling times and standardized solvent transport offer a high standard of reproducability and reliability for dissolution tests.
Also the economical aspect will show that automated sampling offers advantages as the operator does only need to fill the flasks and introduce the samples, thereafter the system operates automatically. Using a PTFC-2 fraction collector means that the way of analysis is open for spectrometer or LC. The filled vials within the vial dish are manually moved to the analyser and either manually injected or transferred to an auto-injection system.
A typical semi automated DFC 100 dissolution test system is composed of the following instruments:
PTWS 100 Dissolution Bath, PTFE tubing installation, 8 channel Peristaltic-, Syringe- or Piston Pump, and a PTFC-2 Fraction Collector. Media Refilling can be automated, too using a 16 channel pump and the refilling valve block inside the PTFC-2.


ptws310-dissolution-tester

PTWS-310 Dissolutie Tester

DFC 310 including PTWS 310 Bath

Semi Automated Dissolution Tester

Whenever automated sampling from a Dissolution Bath is required the PTFC-2 Fraction Collector together with a pump offers an ideal choice. The control of the Fraction Collector with respect to sampling times, dosage volumes, media refilling and pump drive is done via the keyboard and Display or Testing Method File of the PTWS 310 dissolution bath. Enter sampling times, program EPE auto sampling time or call the required Method and connect the system components together for a semi automated operation.
The PTWS 310 is equipped with a Tablet Drop Magazine and the Auto Sampling Probe EPE, which lowers the sampling tubes into the vessels while sampling and rises them at the end of a cycle out of the media. The EPE can be equipped with an ITM Individual Media Temperature Probe system, recording the media temperature while sampling. Correctly positioned sampling tubes only immersed while sampling, equal sampling times and standardized solvent transport offer a high standard of reproducability and reliability for dissolution tests.
Also the economical aspect will show that automated sampling offers advantages as the operator does only need to fill the flasks and introduce the samples, thereafter the system operates automatically. Using a PTFC-2 Fraction Collector means that the way of analysis is open for spectrometer or LC. The filled vials within the vial dish are manually moved to the analiser and either manually injected or transferred to an autoinjection system.

A typical semi automated dissolution test system DFC 310 is composed of the following instruments:
PTWS 310 Dissolution Bath, manual Tablet Drop Magazine, EPE Auto Sampling System, ITM Temperature Monitoring System, PTFE tubing installation, 8 channel Peristaltic-, Syringe- or valve-less Piston Pump, and a PTFC-2 Fraction Collector. Refilling can be automated, too using a 16 channel pump and a refilling valve block inside the PTFC-2.


PTWS-610 dissolution tester

PTWS-610 dissolutie tester

DFC 610 including PTWS 610 Bath

Semi Automated Dissolution Testing

Whenever automated sampling from a Dissolution Bath is required the PTFC-2 fraction collector together with a pump offers an ideal choice. The control of the Fraction Collector with respect to sampling times, dosage volumes, media refilling and pump drive is done via the keyboard and Display or the Method Filing System of the PTWS 610 dissolution bath. Enter sampling times, program EPE auto sampling time or call the required Testing Method and connect the system components together for a semi automated operation.
The PTWS 610 is equipped with a manual Tablet Drop Magazine, the Auto Sampling Probe EPE, which lowers the sampling tubes into the vessels while sampling and rises them at the end of a cycle out of the media. The EPE can be equipped with an ITM Individual Media Temperature Probe System, recording the media temperature while sampling. Correctly positioned sampling tubes only immersed while sampling, equal sampling times and standardized solvent transport offer a high standard of reproducability and reliability for dissolution tests.
Also the economical aspect will show that automated sampling offers advantages as the operator does only need to fill the flasks and introduce the samples, thereafter the system operates automatically. Using a PTFC-2 fraction collector means that the way of analysis is open for spectrometer or LC. The filled vials within the vial dish are manually moved to the analiser and either manually injected or transferred to an autoinjection system.

A typical semi automated DFC 610 dissolution test system is composed of the following instruments:
PTWS 610 Dissolution Bath, manual Tablet Drop Magazine, EPE Auto Sampling System, ITM Temperature Monitoring System, PTFE tubing installation, 8-channel Peristaltic-, Piston-, or Syringe Pump, and a PT-FC2 Fraction Collector. Refilling can be automated, too using a 16 channel pump and a refilling valve block inside the PTFC-2.


PTWS1210_dissolutie-tester

PTWS-1210 dissolutietester

DFC 1210 including PTWS 1210 Bath

Semi Automated Dissolution Testing

Whenever automated sampling form a Dissolution Bath is required the PTFC-12 Fraction Collector together with a pump offers an ideal choice. The control of the Fraction Collector with respect to sampling times, dosage volumes, media refilling and pump drive is done via the keyboard and Display or the testing Method Filing System of the PTWS 1210 dissolution bath. Enter sampling times, program EPE auto sampling time or call the required Testing Method and connect the system components together for a semi automated operation.
The PTWS 1210 is equipped with a manual Tablet Drop Magazine, the Auto Sampling Probe EPE, which lowers the sampling tubes into the vessels while sampling and rises them at the end of a cycle out of the media. The EPE can be equipped with an ITM Individual Media Temperature Probe System, recording the media temperature while sampling. Correctly positioned sampling tubes only immersed while sampling, equal sampling times and standardized solvent transport offer a high standard of reproducability and reliability for dissolution tests.
Also the economical aspect will show that automated sampling offers advantages as the operator does only need to fill the flasks and introduce the samples, thereafter the system operates automatically. Using a PTFC-12 Fraction Collector means that the way of analysis is open for spectrometer or LC. The filled vials within the vial dish are manually moved to the analiser and either manually injected or transferred to an autoinjection system.

A typical semi automated DFC 1210 dissolution test system is composed of the following instruments:
PTWS 1210 Dissolution Bath, manual Tablet Drop Magazine, EPE Auto Sampling System, ITM Temperature Monitoring System, PTFE tubing installation, 16 channel Peristaltic-, Piston-, or Syringe Pump, and a PTFC-12 Fraction Collector. Refilling can be automated, too using a 24 channel pump and a refilling valve block inside the PTFC-12.


DT70-dissolutie-tester

DT70 dissolutie tester

DFC 70 including PT-DT70 Bath

Semi Automated Dissolution Testing

Whenever automated sampling is required the PTFC-2 Fraction Collector together with a pump offers an ideal choice. The control of the PTFC-2 Fraction Collector with respect to sampling times, dosage volumes, refilling and pump drive is done via the keyboard of the PTFC-2. Enter sampling times, interval time, and sampling volume at the keyboard of the PTFC-2 and connect the system components together for a semi automated operation.
Correctly positioned sampling tubes which pass through the drive head of the PT-DT70, equal sampling times and standardized solvent transport offer a high standard of reproducability and reliability for dissolution tests.
Also the economical aspect will show that automated sampling offers advantages as the operator does only need to fill the flasks and introduce the samples, thereafter the system operates automatically. Using a PTFC-2 Fraction Collector means that the way of analysis is open for spectrometer or LC. The filled vials within the vial dish are manually moved to the analiser and either manually injected or transferred to an autoinjection system.

A typical semi automated DFC 70 dissolution test system is composed of the following instruments:
PT-DT70 Dissolution Bath, In-Situ Sampling Probes, PTFE tubing installation, 8-channel Peristaltic-, Syringe- or Piston Pump, and a PTFC-2 Fraction Collector. Refilling can be automated, too using a 16 channel pump and a refilling valve block inside the PTFC-2.


DSR-M_fractie-verzamelaar

DSR-M dissolutie robot

DSR Auto Sampler

Semi Automated Dissolution Testing

Manual sampling from a Dissolution Test Instrument is not only time consuming but also limits the reproducibility and is close to impossible if sustained release products have to be analysed over prolonged time periods. The Pharma Test DSR (Dissolution Sampling Robot) provides a neat solution to this automation procedure.

To offer the highest volume precision, between 6 and 8 valve-less Piston Pumps are used for sample removal and media refilling (if required). No time consuming pump calibration is needed. The advanced design of the system means that it is always ready for operation and as the pump is already built-in the system saves a lot of bench space.
The sample preparation station, Z-arm and needle, can be used to dispense into sealed HPLC vials or dilute samples. Keeping the samples in sealed vials helps to avoid evaporation, specially if sustained release samples are tested.
The DSR is connected to a Pharma Test PTWS series Dissolution Bath. Usually the sampling probes inside the Dissolution Bath are connected to the EPE Auto Sampling Manifold which is available for the following instruments: PTWS 310, PTWS 610 or PTWS 1210. The motorized EPE lowers the sample probes into the corresponding sampling position which is pre-set for either 500 or 900 ml total media volume. A trigger signal starts the DSR sampling pumps so that the preset volume is withdrawn and dispensed into the vials or tubes which are in the sample rack holder. Only one sample line is required from the Dissolution Tester via the sampling manifold as all liquid sampling and refilling is made through the same tubing. So no need for extra return tubing for refilling and automated tube flushing previous to the consequent sampling interval.
If the DSR is connected to a PTWS 310, PTWS 610, PTWS 1210 sampling information is entered via the keyboard inside the Dissolution Bath or called from the exting Testing Method Filing System. Sample handling information, such as Dilution Factor, Sample Transfer into empty septa closed vials is programmed at the keypad of the DSR.

A typical automated System including the DSR includes the following equipment: PTWS 310 Dissolution Bath, manual Tablet Drop Magazine, EPE Auto Sampling Manifold, PTFE tubing installation, DSR Sampling Robot.


dissolution fraction collector

PTFC-2 Fraction Collector

PTFC-2 Fraction Collector

Semi Automated Tablet Dissolution

The PTFC-2 Fraction Collector can be attached to any PTA Dissolution Bath. Using either a Peristaltic-, Syringe- or a valve-less Piston Pump the dissolution media is directly sampled into covered glass vials inside the sampling dish of the PTFC-2.
Depending on the system configuration sampling information such as interval timing and total number of sampling sequences is either programed at the keyboard of the connected dissolution bath or directly at the PTFC-2 panel (DFC 70).
Individual Pinch Valves separately connected to each vessel are used to switch the liquid flow. Previous to a sampling sequence the media is circulated within a closed loop betwen the dissolution vessels and the PTFC-2. As soon as the concentration of the media is equilibrated the pinch valves open for samling. At the end of a sampling sequence all tubes are automatically emptied. Adding an extra set of valves and a pump with more channels the PTFC-2 can also re-fill the sampled media.

A typical semi automated Dissolution Testing System including a PTFC-2 consist of:

PTWS 100 Dissolution Bath, In-Situ Sampling Probes, PTFE tubing, 8-channel Peristaltic Pump, PTFC-2 Fraction Collector. Automated media refilling is possible using a 16-channel pump and the re-filling valve block inside the PTFC-2.